Hepatocyte-Specific Contrast-enhanced MRI for Quantitative Assessment of Liver Function in Children
نویسندگان
چکیده
Objectives: The liver is a complex, multifunctional organ involved in a variety of critical processes. Accurate determination of liver function in children is difficult and current biomarkers often fail to truly assess functional capacity. Advances in magnetic resonance imaging (MRI) with hepatocyte-specific, gadolinium-based agents have enabled improved liver imaging. Since a functional hepatocyte is essential for timely elimination of these agents, hepatic retention may correlate with impaired function. We aimed to determine the utility of quantitative measures of liver enhancement with contrast-enhanced MRI as a biomarker to serve as a global indicator of whole organ function in children and young adult patients with primarily pediatric pathology.
منابع مشابه
Automatic Prostate Cancer Segmentation Using Kinetic Analysis in Dynamic Contrast-Enhanced MRI
Background: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) provides functional information on the microcirculation in tissues by analyzing the enhancement kinetics which can be used as biomarkers for prostate lesions detection and characterization.Objective: The purpose of this study is to investigate spatiotemporal patterns of tumors by extracting semi-quantitative as well as w...
متن کاملNoninvasive assessment of hepatic fibrosis using gadoxetate-disodium-enhanced 3T MRI.
INTRODUCTION Gadoxetate-disodium is a liver-specific MR contrast agent absorbed by hepatocytes via organic anion transporting polypeptide 1B3 and is excreted into the biliary system by multidrug resistance-associated protein 2. It has been suggested that relative parenchymal enhancement on hepatocyte phase image is associated with hepatic function. However, it is not clear whether gadoxetate-di...
متن کاملVascular assessment of liver disease—towards a new frontier in MRI
Complex haemodynamic phenomena underpin the pathophysiology of chronic liver disease. Non-invasive MRI-based assessment of hepatic vascular parameters therefore has the potential to yield meaningful biomarkers for chronic liver disease. In this review, we provide an overview of vascular sequelae of chronic liver disease amenable to imaging evaluation and describe the current supportive evidence...
متن کاملGd-EOB-DTPA-enhanced MRI for evaluation of liver function: Comparison between signal-intensity-based indices and T1 relaxometry
Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a paramagnetic hepatobiliary magnetic resonance (MR) contrast agent. Due to its OATP1B1/B3-dependent hepatocyte-specific uptake and paramagnetic properties increasing evidence has emerged to suggest that Gd-EOB-DTPA-enhanced MRI can be potentially used for evaluation of liver function. In this paper we compare the diagn...
متن کاملMRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score
Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating the liver function as expressed by the MELD score. 3 T MRI rela...
متن کامل